程俊文; 吴学谦; 孙培虎; 吴庆其; 贺亮; 付立忠; 胡传久; 李海波; 魏海龙
浙江省林业科学研究院浙江省森林资源生物与化学利用重点实验室; 丽水市食用菌研究开发中心; 浙江益圣菌物发展有限公司; 丽水市食用菌研究开发中心浙江益圣菌物发展有限公司

【中文摘要】 通过设3个浓度的药物组和空白对照组,分别进行脏器指数测定,ConA诱导的小鼠脾淋巴细胞转化试验,绵羊红细胞诱导小鼠DTH试验,小鼠血清溶血素测定,抗体生成细胞检测,小鼠腹腔巨噬细胞吞噬鸡红细胞试验,小鼠碳廓清试验,NK细胞活性测定试验。结果表明,灵芝多糖提取物胶囊能增加ConA诱导的小鼠脾淋巴细胞的增殖能力和小鼠左后足跖部厚度差24 h测量值,提高小鼠血清溶血素抗体积数和溶血空斑数。表明灵芝多糖提取物胶囊具有较强的免疫调节作用。

【英文摘要】 Three concentrations of polysaccharide extracts of Ganoderma capsule and a control groups had been divided.The im-mune function of polysaccharide extracts of Ganoderma capsule was studied by a serial experiments including spleen and thymus weight ratio,ConA-induced mice lymphocyte transformation test,DTH assay,serum hemolysin determinations,antibodies forma-tion in spleens,macrophage swallow chicken erythrocyte test,monocyte-macrophage carbon grain elimination test and NK cells living activities assay.The results showed that polysaccharide extracts of Ganoderma capsule increased spleen lymphocytes pro-liferation of mice induced by ConA and the Left-hind feet thickness's difference between 24 h and 0.The formation of antibod-ies and the plague-forming cell were improved.The polysaccharide extracts of Ganoderma capsule possessed strong effect of im-mune regulation.

【中文关键词】 灵芝多糖提取物胶囊; 免疫功能; 小鼠
【英文关键词】 Polysaccharide extracts of Ganoderma capsule; Immune function; Mice
【基金】浙江省科技厅科研院所研究开发项目(2007F10004);; 省院合作项目(2008SY02);; 948项目(2008-4-64);; 丽水市科技项目(20074022)的部分研究内容

【文献出处】 中国食用菌,Edible Fungi of China,编辑部邮箱,2009年06期 【DOI】CNKI:SUN:ZSYJ.0.2009-06-019