陈春霞
福建三明真菌研究所 三明 365000

【中文摘要】 羧甲基茯苓多糖(Carboxymethylpachymaran,CMP)100μg/ml对人外周血淋巴细胞(HPBL)诱生肿瘤坏死因子(TNF)、白细胞介素-6(IL-6)、干扰素-γ(IFN-γ)的效价比常规诱生分别高7.4、0.5、10.9倍;CMP100μg/ml与PHA10gg/ml或Con A5μg/ml复合诱生TNF、IL-6、IFN-γ的效价比常规诱生分别高31.5、1.8、28.9倍;CMP100μg/ml与PHA10μg/ml、Con A5μg/ml三联诱生TNF、IL-6、IFN-γ的效价比常规诱生分别高90.2、4.7、63.2倍;CMP100μg/ml与PHA10μg/ml复合诱导HPBL产生粒-巨噬细胞集落刺激因子(Granulocyte-macrophage colony-stimulatingfactor,GM-CSF)的效价可以达到8×104U/ml以上。

【英文摘要】 It was proved that the titer of CMP 100μg/ml on tumor necrosis factor (TNF), Interleukin -6(IL -6), interferon-γ (IFN-γ) induced from human peripheral blood lymphocyte (HPBL) was 7.4, 0.5, 10.9 times greater than that produced by conventional induction resp., that the titer of CMP 100μg/ml combined with PHA 10μg/ml or Con A 5μg/ml on TNF ,IL-6 IFN-γ was 31.5, 1.8, 28.9 times greater than that produced by conventional induction resp., and that the titer of CMP 100μg/ml combined with PHA 10μg/ml and Con A 5μg/ml on TNF, IL-6, IFN-γ was 90.2, 4. 7, 63.2 times greater than that produced by conventional induction resp. . While the titer of CMP 100μg/ml combined with PHA 10μg/ml on the production of granulocyte -macrophage colony - stimulating factor (GM - CSF) induced from HPBL would be greater than 8×104U/ml.

【中文关键词】 羧甲基茯苓多糖; 促诱生; 肿瘤坏死因子; 白细胞介素-6; 干扰素为-γ; 粒-巨噬细胞集落刺激因子
【英文关键词】 Carboxymethylpachymaran; Induction stimulation; Tumor necrosis factor; Interleukin-6; Inter-feron-γ; Granulocyte-macrophage colony-stimulating factor

【文献出处】 食用菌学报,Acta Edulis Fungi,编辑部邮箱,1998年02期 【DOI】CNKI:SUN:SYJB.0.1998-02-003