尚德静; 崔乔; 高林
辽宁师范大学生命科学学院; 辽宁师范大学生命科学学院; 大连医科大学附属二院 大连116029 ; 大连116029 ; 大连116027

【中文摘要】 灵芝硒多糖SeGLP - 1由葡萄糖、甘露糖、木糖、半乳糖和鼠李糖组成 ,与灵芝多糖一样是由α -糖苷键连接的吡喃多糖 ,硒在多糖内极可能是以O =Se =O的形式结合。给移植肝腹水癌HCa -f的小鼠每日注射 5 0mg/kg的SeGLP - 1,15d后抑癌率可达 80 % ,说明SeGLP - 1的抑癌作用与其分子组成和分子结构的变化有关

【英文摘要】 The polysaccharide containing selenium in Ganoderma lucidum (SeGLP-1), a kind of pyranose linked by α-glucoside bond as GLP-1, was isolated and purified from fermented mycelia of Ganoderma lucidum rich in selenium. Glu,Man,Xyl,Gal and Rha were identified as the components of SeGLP 1 by GC and TLC. The results from IR, 77 Se NMR, 13 C NMR and Laser Raman spectra showed that the selenium structure of SeGLP 1 activity center was O=Se=O,and CH 3 in OCH 3 group was substituted by selenium. SeGLP-1 could distinctly suppress the growth of tumor cell at a daily dosage of 50mg/kg supplied continuously for 15d with an anti HCa-f tumor rate of 80%. And it was confirmed in our experiment that the anti-tumor effect of SeGLP 1 was related to the changes of its molecular components and structure.

【中文关键词】 灵芝硒多糖; 抑癌作用; 分子结构
【英文关键词】 Polysaccharide containing selenium in Ganoderma lucidum (SeGLP-1); Anti-tumor activity; Molecular structure
【基金】辽宁省教委重点科研项目 (95 12 10 0 3)

【文献出处】 食用菌学报,Acta Edulis Fungi,编辑部邮箱,2001年03期 【DOI】CNKI:SUN:SYJB.0.2001-03-006