洛巴口蘑滤液中多糖蛋白复合物的抗肿瘤机制
ANTITUMOR MECHANISM OF POLYSACCHARIDE-PROTEIN COMPLEX FROM THE CULTURE FILTRATE OF TRICHOLOMA LOBAYENSE
刘方 黄容春 邢来君 赵力 张树庭
摘 要：从洛巴口蘑培养滤液中分离出一种具有抗肿瘤性的多糖蛋白复合物(PSPC).PSPC在细胞水平有能力恢复和增强带瘤鼠腹腔浸出细胞的吞噬功能和T细胞的促分裂活性.在分子水平,PSPC能恢复带瘤鼠脾细胞和腹腔浸出细胞内IFN-γ基因的表达水平.另外,PSPC能够下调带瘤鼠脾细胞内"抗细胞因子"TGF-β的表达水平.因此,PSPC的抗肿瘤机制可归咎于寄主介导的免疫调节作用.
关键词：多糖,蘑菇,细胞因子,免疫调节
分类号：Q939.93 文献标识码：A
文章编号：1007-3515-62000)03-0396-0400
作者单位：刘方（天津南开大学微生物系 天津 300071）
黄容春（香港中文大学生物系 香港）
邢来君（天津南开大学微生物系 天津 300071）
赵力（天津医院 天津 300211）
张树庭（香港中文大学生物系 香港）
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